535
edits
Changes
no edit summary
|colspan="2"|[[File:VPA_3D.png|300px]]<ref name="[46]">Pubchem (Last modified: 2019-12-08) Accessed on 12 December 2019, at [https://pubchem.ncbi.nlm.nih.gov/compound/Valproic-acid#section=3D-Conformer''https://pubchem.ncbi.nlm.nih.gov/compound/Valproic-acid#section=3D-Conformer''].</ref>
|-
|}</div>
== General ==
Valproate (VPA) is a drug used in the treatment of epilepsy, bipolar disorder and spinal muscular atrophy <ref name=”[15]”> Sodium valproate (Epilim, Epival, Episenta). (2018, June 5) , at [https://www.netdoctor.co.uk/medicines/brain-nervous-system/a6665/epilim-sodium-valproate/ “https://www.netdoctor.co.uk/medicines/brain-nervous-system/a6665/epilim-sodium-valproate/”].</ref>
. VPA is used to control of epileptic seizures, divided in two subcategories: focal and generalized seizures.
VPA was originally synthesized by Burton in 1882 and used as an organic solvent. Its antiepileptic effect was by accident discovered almost 100 years later by Meunier et al. (1963). It was registered as a drug in 1964 in France and later in many other countries. <ref name=”[35]”> , . Drugbank, Valproic Acid Retrieved from November 25, 2019, at [https://www.drugbank.ca/drugs/DB00313
“https://www.drugbank.ca/drugs/DB00313”].</ref><ref name=”[41]”> Perucca, E. (2012, August 29). Pharmacological and Therapeutic Properties of Valproate ,CNS Drugs
October 2002, Volume 16, Issue 10, pp 695–714. Retrieved November 28, 2019, at [https://link.springer.com/article/10.2165/00023210-200216100-00004 “https://link.springer.com/article/10.2165/00023210-200216100-00004.”]
</ref><ref name=”[45]”> Padmanabhan, R., Abdulrazzaq, Y. M., & Bastaki, S. M. A. (2000). Valproic acid-induced congenital malformations: Clinical and experimental observations , Congenital anomalies 40(4), 259-268. Retrieved December 9, 2019, at [https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1741-4520.2000.tb00923.x“https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1741-4520.2000.tb00923.x.”].</ref>
==Structure and interaction with albumin==
