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The two large proteins found on the outside of viral particles are hemagglutinin (HA) and neuraminidase (NA). HA is a protein that mediates binding of the virion to target cells and entry of the viral genome into the target cell, and therefore plays an important role in infecting healthy cells.
NA is involved in releasing the progeny viruses once a cell has been infected and has started producing the virus itself<ref name="Arti14">Native Morphology of Influenza VirionsA penetrates host mucus by cleaving sialic acids with neuraminidase, Frontiers in microbiologyVirology journal , 20112013, Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249889PMC3842836/</ref>.
