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→History of Sepsis
== History of Sepsis ==
The oldest report that associates sepsis with wounds goes all the way back to a discovery by Edwin Smith. In 1826 he found a papyrus in Luxor, Egypt, which was written around 1600 BC. This papyrus seemed to be a copy of an even older manuscript written around 3000 BC. In this manuscript, 48 cases of traumatic lesions between wounds, fractures, and dislocations are mentioned. Clear references to fever as a secondary phenomenon in the wound – with emphasis on the fever as a part of the monitoring of the patients’ evolution - are found in five out of the forty-eight references. Thus, without being familiar with the concept of infection or inflammation, these Egyptian physicians were able to identify some clear signs of what we know nowadays as local suppuration and systemic infection. <ref name="Arti6">The History of Sepsis from Ancient Egypt to the XIX Century, (M. C. F. P. E.-L. Azevedo (Ed.); p. Ch. 1). IntechOpen, 2012, Botero, J. S. H., https://doi.org/10.5772/51484 </ref><ref name="Arti7"> The last 100 years of sepsis. American Journal of Respiratory and Critical Care Medicine, 173(3), 256–263, 2006, Vincent, J.-L., & Abraham, E., https://doi.org/10.1164/rccm.200510-1604OE </ref><ref name="Arti8"> Sepsis History, https://www.news-medical.net/health/Sepsis-History.aspx, 2018, Ryding, S. </ref>
The first reported use of the word sepsis (σηψις) is in a poem of Homer in the Iliad, where it is a derivative of the word sepo (σηπω), which translates to “I rot”. Yet, the first use of sepsis in a medical context can be found in the Hippocratic corpus, written around 400 BC. The use of this word was related to the phenomenon discovered by the Egyptians. Hippocrates described sepsis as a dangerous odiferous biological decay that could occur in the body. Furthermore, it was believed that this decay took place in the colon and from there “dangerous principles” were released, which could cause “auto-intoxication”. Hippocrates was the first one to try and find antisepsis properties and potential medicinal compounds.<ref name="Arti6">The History of Sepsis from Ancient Egypt to the XIX Century, (M. C. F. P. E.-L. Azevedo (Ed.); p. Ch. 1). IntechOpen, 2012, Botero, J. S. H., https://doi.org/10.5772/51484 </ref><ref name="Arti9">Sepsis and septic shock: a history. Critical Care Clinics, 25(1), 83–101, viii, 2009, Funk, D. J., Parrillo, J. E., & Kumar, A., https://doi.org/10.1016/j.ccc.2008.12.003</ref><ref name="Arti8"> Sepsis History, https://www.news-medical.net/health/Sepsis-History.aspx, 2018, Ryding, S. </ref>
In 1964 Dr. Edward Frank from Boston published a management strategy for septic shock. This strategy consisted of continuous monitoring of systemic arterial pressure, central venous pressure, cardiac output, urinary output, blood volume, blood chemistries, gases, pH and electrolytes. Some of these are still used nowadays, such as blood monitoring and urinary output. Aided by the discovery of antibiotics by Alexander Fleming, it was also recommended to find the cause of the infection.<ref name="Arti10">The History of Sepsis Management Over the Last 30 Years. Elsevier, 15(2), 116–117, 2014, Zehava L., N., https://daneshyari.com/article/preview/3235901.pdf </ref>
== Mechanism of Acute Inflammation ==
